The integration of biomolecular engineering, nanotechnology and biology is expected to produce major breakthroughs in medical diagnostics and therapeutics. Due to the size-compatibility of nano-scale structures with proteins and nucleic acids, the design, optimization and application of nanoprobes, nanocarriers and molecular machines provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection and therapy. Recent advances include the development of engineered nucleases and multi-functional nanoparticles for biological and medical applications.
In this talk I will present the design and optimization of CRISPR/Cas9 systems for treating single-gene disorders, and the development and application of multi-functional nanoparticles for molecular imaging, cell tracking and biomolecule detection. The opportunities and challenges in nanomedicine and therapeutic genome editing are also discussed.