Biomedical Engineering

Biomolecular Engineering for Genome Editing and Nanomedicine

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Speaker: 

Gang Bao, Ph.D.

Date: 

Friday, October 21, 2016 - 12:00pm to 1:00pm

Location: 

SEC 204

Abstract: 

The integration of biomolecular engineering, nanotechnology and biology is expected to produce major breakthroughs in medical diagnostics and therapeutics. Due to the size-compatibility of nano-scale structures with proteins and nucleic acids, the design, optimization and application of nanoprobes, nanocarriers and molecular machines provide unprecedented opportunities for achieving a better control of biological processes, and drastic improvements in disease detection and therapy. Recent advances include the development of engineered nucleases and multi-functional nanoparticles for biological and medical applications. In this talk I will present the design and optimization of CRISPR/Cas9 systems for treating single-gene disorders, and the development and application of multi-functional nanoparticles for molecular imaging, cell tracking and biomolecule detection. The opportunities and challenges in nanomedicine and therapeutic genome editing are also discussed.