Biomedical Engineering

Imaging and Therapy Directed at Cancer Stroma Cells

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Speaker: 

Chun Li, Ph.D.

Date: 

Friday, October 14, 2016 - 12:00pm to 1:00pm

Location: 

SEC 204

Abstract: 

Tumor stroma is characterized by the presence of a large number of cancer associated fibroblasts, macrophages, endothelial cells, and other immune cells. These cells are often present in aberrantly high numbers in tumor microenvironment that are distinctly different from normal cells. Targeting stroma cells proves a unique opportunity for cancer imaging and therapy. We have exploited the use of nanoparticles and imaging probes directed at cancer associated fibroblasts and macrophages for imaging therapy-induced cell death, assessing host response to tumor progression and suppression, and potentiation of conventional chemoradiotherapy. These work will be presented and discussed in the context of pancreatic cancer and ovarian cancer, and inflammatory diseases in my talk.